Articles

  • [Application Note] PaRTI-Seq™️ Workflow for Samples of Small Volume

    Collecting large volumes of biospecimen such as CSF or vitreous humour fluid can be challenging. Micronbrane developed a modified protocol of effective processing for scarce liquid biopsy using the Devin™ filter. This protocol is followed by the case study on processing clinical samples of 50 μL (0.05ml) vitreous humour fluid. Learn more about how the Devin™ filter enhances detection efficiency with the PaRTI-Seq™ workflow in this Application Note.

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  • Matters of the brain: empowering diagnosis of meningitis and encephalitis with mNGS

    Meningitis and encephalitis are two neurological diseases with devastating clinical impacts on patients, due to their typically late diagnosis and life-threatening prognosis. Read the new article to learn how early detection provides a significant breakthrough in the quality and timeliness of clinical diagnosis in this short article

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  • Nosocomial Infections: Early Diagnosis by mNGS

    Each year globally 45 billion US dollars is spent annually on fighting nosocomial infections in hospitals. See new infographic article to learn how early diagnosis can improve public health and decrease the burden for healthcare providers

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  • [White Paper] The Current Landscape of Clinical Bioinformatics: Bottlenecks and Alternatives

    Inconsistent metagenomic (mNGS) databases, sophisticated software, specialized training and high maintenance informational (IT) systems is a growing headache for clinical bioinformatics nowadays. What challenges and alternatives exist today on the market for pathogen analysis using NGS in precision medicine? Read the newest White Paper prepared for you by Micronbrane Medical about potential of developing modern clinical bioinformatics solution for fast and accurate diagnostics of infectious diseases.

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  • A Streamlined Way to Facilitate Pathogen Detection

    Certain epidemiological contexts require robust, versatile and on-demand approaches for pathogen detection that entail minimal logistical and financial constraints. These approaches are increasingly sought after as first-line solutions for the identification and surveillance of pathogen outbreaks, namely in contexts of epidemics and pandemics in low-income countries or remote regions, as well integrated in the context of emergency readiness protocols.

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  • [White Paper] Optimizing sequencing costs in metagenomics. How to reduce costs of pathogen detection in with PaRTI-Seq™

    Optimizing sequencing costs in metagenomics is crucial in precision medicine today like never before. How to reduce costs of pathogen detection in clinical microbiology? Read the newest White Paper about mitigating sequencing cost with novel technology PaRTI-Seq™

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  • Human methylated DNA removal method and comparison with Devin®

    Nowadays there are several methods of human DNA removal, including differential cell size-based methods, chemical/enzymatic treatment methods etc. In this article we overview human methylated DNA removal methods and compare their efficacy with recently launched Devin® filter from Micronbrane Medical.

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  • Differential lysis depletion methods – drawbacks, shortcomings and alternatives

    Current diagnosis and research protocols use lysis depletion to avoid host DNA interference and further detect the pathogen involved in infectious diseases. But are all lysis depletion methods just as efficient in reducing host DNA and preserving the microbial community intact? Let's find out how most host DNA depletion methods work compared to the newly developed ones.

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  • How ZISC technology improves leukodepletion

    Biofouling resistance of PP membranes is significantly improved with surface zwitterionization for leukocyte reduction filters. Micronbrane enhanced this technique and developed zwitterionic interface ultra-self-assemble coating technology (global patent) used in Devin filter. The developed membrane can remove more than 95% of nucleated cells from whole blood samples within just 5 minutes. Let's see how it works.

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  • Biochemical and Genetic Basis of Antimicrobial Resistance

    Many threatening pathogens are now resistant to multiple classes of antimicrobial agents. A study tested 500 Streptomyces strains isolated from soil against 21 antibiotics of different class found that all the strains were multidrug resistant to at least 7 of the tested antibiotics (D’Costa et al., 2006). These multidrug-resistant (MDR) organisms cause infections that may compromise effective therapy and limit treatment options.

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  • Application of Next Generation Sequencing in Diagnosis of Culture-negative Endocarditis

    Infective endocarditis is inflammation of endocardium that usually affects heart valves. Mortality rate of the disease is up to  30% in 1st year for many malignant cancers. The most common risk factors for infective endocarditis include previous heart damage, recent heart surgery or poor dental hygiene. According to report of National Organization for Rare Diseases, people over the age of 50 with prosthetic heart valves or cardiac pacemakers are more prone to develop endocarditis.

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  • Is cfDNA an effective tool for rapid diagnostics of infectious diseases

    Many DNA sequences, including cfDNA fragments, are species-specific and with the development of next-generation sequencing (NGS) technology, these molecules have been described as a promising, non-invasive tool for the early detection of several human diseases, including sepsis for which the latest research have reported significantly elevated fractions of cfDNA from retrotransposable elements in blood.

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  • Whole Blood Pathogen Detection for Antibiotic Resistance Genes Identification

    It has been nearly two years since the global healthcare resources have been diverted into the prolonged fight against the SARS-CoV2 pandemic, often being forced to put other medical issues and emergencies on hold. Aside from the undeniable threat of the COVID-19 crisis, there are other urgent challenges to the health of the general population, such as the accelerating development of resistance to antimicrobials, seen among many harmful pathogens.

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  • Microorganisms pathogenicity and virulence

    Medicine and medical technology have evolved rapidly in the past decades. Infectious diseases that were once impossible to confirm can now be diagnosed and cured efficiently. Unfortunately, in the face of advanced treatment, microorganism pathogenicity and virulence grew stronger to survive. Severe infections still take medical professionals into a race against time to accurately diagnose pathogenic microorganisms and treat patients with the right antimicrobial drug.

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  • Detection of Pathogens in clinical samples via MALDI-TOF MS Technology – Benefits vs Challenges.

    One of the most commonly used methods for microbial identification is 18S and 16S ribosomal RNA sequencing. Currently a new technology, MALDI-TOF MS (matrix-assisted laser desorption ionization-time of flight mass spectrophotometry) has emerged as a potential technique for the diagnosis of microbes in clinical specimens. This technique is very rapid, has high specificity and sensitivity as compared to other conventional methods of pathogen identification. Microbiologists have used this technique not only for diagnostic purposes but also in epidemiological studies, strain identification and typing, detection of toxins, identification of biological warfare agents, water, and foodborne pathogen, detection of antimicrobial resistance, and identification of urinary tract and blood pathogen.

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