Our products reduce the contamination, complexity, and cost of every step of the mNGS workflow so you can accelerate your research, make breakthrough discoveries, or improve patient outcomes.
Micronbrane products are designed as connected mNGS workflow components. Start with the bottleneck your lab needs to solve, then route to the product page that fits the sample-preparation or analysis step.
To mitigate these risks of nucleic-acid cross-contamination in the lab environment, strict cleaning procedures for lab surfaces and equipment are crucial. Micronbrane Medical’s XNA Decontaminating Spray offers a premixed, stabilized solution that degrades nucleic acids, DNases, RNases, and other surface enzymes. It works by causing oxidative damage to nucleic acid molecules, effectively breaking them down upon contact. Designed for use on clean benches, incubators, manual pipettes, PCR hoods, and more, XNA Spray ensures a contaminant-free lab environment with the convenience of a ready-to-use, long-lasting product.
Custom-made oral, nasal, nasopharyngeal swabs, and rapid diagnostic test kits.
Start the process off right with collection devices that quickly and cleanly collect all types of biological fluids. Devices can be sterile/non-sterile and comply with ISO13485, GMP and QMS standards.
For more information about our collection devices please refer to our product catalog.
Host interference is a major challenge in mNGS due to the much larger size of the host genome compared to microbial genomes. Even trace amounts of host DNA/RNA can overwhelm microbial reads, reducing accuracy and making it harder to detect low-abundance species.
The Devin™ Host Depletion filter utilize a patented technology called Zwitterionic Interface ultra-Self-assemble Coating (ZISC). Alternating charged ions, rather than pore size (15-20µm), selectively retains host nucleated cells on the membrane while allowing bacterial, viral, fungi, and parasite communities to pass through unaltered.
The Devin Microbial DNA Enrichment Kit is a fast and simple genomic nucleic acid purification protocol specifically designed using mNGS-grade reagents to minimize contamination. The kit begins with the Devin filter to deplete host nucleated cells from liquid biopsies. Extractions with the kit, after host depletion, are also compatible with automated systems, facilitating high-throughput NGS assays.
The Unison Ultralow DNA NGS Library Preparation Kit optimizes the preparation of NGS libraries for low-input DNA (as little as 10 pg) extracts. The kit also accelerates DNA library preparations by utilizing a proprietary tagmentation-based method which condenses fragmentation, adapter ligation, and normalization steps into a single step. Specifically optimized for high molecular weight DNA the kit generates library fragments whose sizes are optimal for Illumina platforms at normalized concentrations.
Unison provides you with pure, high-quality DNA extracts that enable multiplexing each sequencing run. By effectively reducing host contamination right from the start, the sequencing depth required to achieve a representative microbiome sample can be reduced by several fold. This reduces sequencing costs and shortens overall sequencing time, depending on the downstream sequencing platforms.
Unison is:
PaRTI-Seq Analysis is designed to overcome the computational and interpretive challenges of metagenomic sequencing by turning complex datasets into clear, actionable results. In research settings, a complimentary RUO version provides downloadable data for exploratory applications. In clinical settings, the pipeline is available through a secure cloud platform or locally via PaRTIBot, delivering PHI-compliant workflows, curated pathogen databases, and structured clinical reports without the need for in-house bioinformatics expertise.
Devin Host Depletion Filters
Unison Ultralow Library Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kit
Unison Ultralow Library Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kit
Unison Ultralow Library Kit
PaRTI- Seq
Clinical Analysis
Devin Host Depletion Filters
Unison Ultralow Library Prep Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kits
Unison Ultralow Library Preparation Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kits
Unison Ultralow Library Kit
PaRTI-Seq
Clinical Analysis
Devin Microbial Enrichment Kits
Unison Ultralow Library Kits
PaRTI-Seq
Bioinformatics analysis
<30 mins / sample analysis and reporting
Automatic cutoff of background noise
Over 1400 pathogens
Micronbrane Medical technologies enrich our understanding of microorganisms through innovative metagenomic collection devices, novel host depletion, mNGS-grade reagents, advanced metagenomic sequencing assays, automation instrumentation, plus rapid bioinformatic software.
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