Metagenomics offers a unique opportunity to examine microbial genomes without culturing the organisms in an aseptic environment. Moreover, metagenomics Next-Generation Sequencing (mNGS) provides fast and precise identification of all types of known and novel bacteria, viruses, fungi, and parasites, making it a powerful tool for infectious disease testing. We develop mNGS products that remove the barriers to ubiquitous use in all types of settings.
Custom-made oral, nasal, nasopharyngeal swabs, and rapid diagnostic test kits.
Start the process off right with collection devices that quickly and cleanly collect all types of biological fluids. Devices can be sterile/non-sterile and comply with ISO13485, GMP and QMS standards.
For more information about our collection devices please refer to our product catalog.
The presence of larger eukaryotic genomes can obfuscate sequencing signals from microbial genomes. The Devin Host Depletion filter is a proprietary syringe filter that effectively removes host background signals from all liquid biopsies. The patented technology, called Zwitterionic Interface Ultra Self-assemble Coating (ZISC), depletes host nucleated cells while allowing bacterial, viral, fungi, and parasite communities to pass through unaltered.
The Devin Microbial DNA Enrichment Kit is a fast and simple genomic nucleic acid purification protocol specifically designed using mNGS-grade reagents to minimize contamination. The kit begins with the Devin filter to deplete host nucleated cells from liquid biopsies. Extractions with the kit, after host depletion, are also compatible with automated systems, facilitating high-throughput NGS assays.
The Unison Ultralow DNA NGS Library Preparation Kit optimizes the preparation of NGS libraries for low-input DNA (as little as 10 pg) extracts. The kit also accelerates DNA library preparations by utilizing a proprietary tagmentation-based method which condenses fragmentation, adapter ligation, and normalization steps into a single step. Specifically optimized for high molecular weight DNA the kit generates library fragments whose sizes are optimal for Illumina platforms at normalized concentrations.
To streamline the entire mNGS workflow, our PaRTI-Seq Analysis ensures fast reporting of results. The platform is curated with up-to-date genome information for thousands of microorganisms. The PaRTI-Seq Analysis pipeline has proper database benchmarking and robust analysis of microbial pathogens with unusual sequence homologies and/or close taxonomic relationships, reducing false-positive or false-negative results. Our PaRTI-Seq Analysis is available by the reaction or as an annual subscription.
PaRTI-Cular’s state-of-the-art computational algorithms provide a complete report within 30 minutes per sample. The cloud-based software also automatically conducts data quality checks, removal of host genome reads, pathogen identification, and statistical analyses.
Devin Host Depletion Filters
Unison Ultralow Library Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kit
Unison Ultralow Library Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kit
Unison Ultralow Library Kit
PaRTI- Seq
Clinical Analysis
Devin Host Depletion Filters
Unison Ultralow Library Prep Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kits
Unison Ultralow Library Preparation Kit
PaRTI-Seq
ROU Analysis
Devin Microbial Enrichment Kits
Unison Ultralow Library Kit
PaRTI-Seq
Clinical Analysis
Devin Microbial Enrichment Kits
Unison Ultralow Library Kits
PaRTI-Cular
Bioinformatics analysis
<30 mins / sample analysis and reporting
Automatic cutoff of background noise
Over 1400 pathogens
Micronbrane Medical technologies enrich our understanding of microorganisms through innovative collection devices, novel host depletion, mNGS-grade reagents, advanced metagenomic sequencing assays, plus rapid bioinformatic software.
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