Every year, about 48 million people are diagnosed with sepsis worldwide. 1 out of 5 people with sepsis die – and this represents 18 to 20% of annual global deaths. Almost half of these are children, with neonatal and pediatric sepsis accounting for 20 million cases. These are devastating numbers.

The Asia-Pacific region has the highest incidence of sepsis in the world – estimates have revealed that up to 1600 per 100,000 people are afflicted with the disease. The death rate in these countries reach as high as 35%. 

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Sepsis is the final common pathway to death for severe infectious diseases

Sepsis is responsible for almost 20% of all deaths worldwide. This was higher than deaths caused by cancer in 2020. Even if patients survive to live another day, they have risks of developing long-term consequences of neurological, psychiatric, and functional disabilities. Sepsis costs a total of $13,4 billion in 2018, more than twice its cost in 2012 as reported by US Medicare. Sepsis is undoubtedly still a complex challenge up till now.

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Invasive Candidiasis – a deadly disease

Candida spp., commensal yeasts that colonize in our gut and on our skin could become lethal pathogens when they overgrow and disseminate into our bloodstream and deep-seated organs (lung, liver, spleen, kidneys, bone, or eye) and then cause invasive candidiasis (IC). Bloodstream infection (BSI), also called candidemia and internal organ infection are two common forms of IC which are the predominant fungal hospital-acquired infections.

Candidemia is one of the most common hospital-associated infections with extremely high mortality rates among patients up to 75% worldwide

Additionally, the cost burden of the disease was substantial high. Invasive candidiasis was estimated as one of the highest healthcare costs of fungal diseases in the United States ($64,723–$153,090 per hospitalization).

Unfortunately, there estimated 3-5 cases with candidemia for every 100,000 persons in the general population, and even higher in hospital or ICU admissions.

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