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Metagenomic Innovations from Collection to Action

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Metagenomic Innovations from Collection to Action

Infectious diseases claim over 18 million lives globally each year.*

A number exacerbated by the low sensitivity and yield of traditional diagnostic methods.

Current pathogen detection methods can fail to provide accurate and timely microbial data, essential for understanding microbial dynamics, developing targeted therapies, and identifying emerging threats. 

A more sensitive and comprehensive microbiological test is needed to improve research capabilities and clinical outcomes.

*WHO 2023 data adjusted to include COVID deaths.

Realizing the Promise of Metagenomic Next-Generation Sequencing (mNGS)

Only mNGS can:
Identifying known and novel
pathogens simultaneously
Detect low-abundance
microorganisms
Profile antimicrobial
resistance genes
Offer insights into microbial
functions and host responses

Despite its promise, mNGS presents challenges because microbes constitute only a tiny fraction of the genomic material in a sample. 

Host, reagent, and environmental contaminants overwhelm microbial signals, leading to decreased detection sensitivity, increased workflow complexities, and higher costs. 

That’s why we develop the products that systematically remove the barriers to mNGS adoption from specimen collection to definitive action, empowering you to quickly and easily implement mNGS.

Infectious diseases claim over 18 million lives globally each year.*

A number exacerbated by the low sensitivity and yield of traditional diagnostic methods.

Current pathogen detection methods can fail to provide accurate and timely microbial data, essential for understanding microbial dynamics, developing targeted therapies, and identifying emerging threats. 

A more sensitive and comprehensive microbiological test is needed to improve research capabilities and clinical outcomes.

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*WHO 2023 data adjusted to include COVID deaths
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Realizing the Promise of Metagenomic Next-Generation Sequencing (mNGS)

Only mNGS can:
Identifying known and novel pathogens simultaneously
Detect low-abundance microorganisms
Profile antimicrobial resistance genes
Offer insights into microbial functions and host responses

Despite its promise, mNGS presents challenges because microbes constitute only a tiny fraction of the genomic material in a sample. 

Host, reagent, and environmental contaminants overwhelm microbial signals, leading to decreased detection sensitivity, increased workflow complexities, and higher costs. 

That’s why we develop the products that systematically remove the barriers to mNGS adoption from specimen collection to definitive action, empowering you to quickly and easily implement mNGS.

Improving Research, Diagnosis, Treatment and Surveillance

Testimonial with Read More/Less
Bora Ergin
PhD, R&D, INTERGEN Genetics and Rare Diseases Diagnosis Research & Application Center



"Because the patients we serve have rare and undiagnosed diseases, we are committed to utilizing the most advanced technologies available. My responsibility is to identify, evaluate, and integrate new testing modalities into our diagnostic repertoire. There is a pressing need for more comprehensive infectious disease testing, and Micronbrane Medical’s products are crucial in enabling us to apply mNGS to quickly and accurately identify causal pathogens, ultimately enhancing outcomes for all our patients."


Testimonial with Read More/Less
Joanne Watkins
BSc MSc CSci MIBMS, Deputy Head of Pathogen Genomics Unit, Public Health Wales



"As a laboratory within Public Health Wales, we use NGS to sequence hundreds of samples a month. For some cultured organisms received, we were not able to get sequencing results for about 30% of those samples due to the high representation of the host genome. However, after using the Devin™ Host Depletion filters, the sequencing failure rate has dropped by two thirds. Given the results, we are looking at other Micronbrane Medical products to make further improvements to service for the benefit of the people of Wales."


Testimonial with Read More/Less
Victor Nizet

"Precise and reliable bacterial identification is key to our basic and translational research in host-pathogen interactions and infectious diseases drug discovery, including work with human samples, tissue culture systems, and animal models. Metagenomic NGS is a powerful emerging tool for these objectives, including new work with probiotics and microbial communities. Micronbrane Medical's PaRTI-Seq assay piqued our interest because of its ability to minimize contamination and enhance signal quality. We are exploring its application to specific microbial genes or pathways involved in infection and antibiotic resistance to support our efforts to develop targeted therapies against multidrug-resistant pathogens."


Testimonial with Read More/Less
Bora Ergin
PhD, R&D, INTERGEN Genetics and Rare Diseases Diagnosis Research & Application Center



“Because the patients we serve have rare and undiagnosed diseases, we are committed to utilizing the most advanced technologies available. My responsibility is to identify, evaluate, and integrate new testing modalities into our diagnostic repertoire. There is a pressing need for more comprehensive infectious disease testing, and Micronbrane Medical’s products are crucial in enabling us to apply mNGS to quickly and accurately identify causal pathogens, ultimately enhancing outcomes for all our patients.”


Testimonial with Read More/Less
Joanne Watkins
BSc MSc CSci MIBMS, Deputy Head of Pathogen Genomics Unit, Public Health Wales



“As a laboratory within Public Health Wales, we use NGS to sequence hundreds of samples a month. For some cultured organisms received, we were not able to get sequencing results for about 30% of those samples due to the high representation of the host genome. However, after using the Devin™ Host Depletion filters, the sequencing failure rate has dropped by two thirds. Given the results, we are looking at other Micronbrane Medical products to make further improvements to service for the benefit of the people of Wales.”


Testimonial with Read More/Less
Victor Nizet

“Precise and reliable bacterial identification is key to our basic and translational research in host-pathogen interactions and infectious diseases drug discovery, including work with human samples, tissue culture systems, and animal models. Metagenomic NGS is a powerful emerging tool for these objectives, including new work with probiotics and microbial communities. Micronbrane Medical’s PaRTI-Seq assay piqued our interest because of its ability to minimize contamination and enhance signal quality. We are exploring its application to specific microbial genes or pathways involved in infection and antibiotic resistance to support our efforts to develop targeted therapies against multidrug-resistant pathogens.”


Simplifying the Path to mNGS

down points

Accurate:
Improves microbial reads with integrated host depletion.

Accelerated:
Delivers results in under 24 hours.

Adaptable:
Accommodates a wide range of sample types and applications.

Affordable:
Reduces sequencing depth and costs.

Automatable:
Boosts efficiency with companion
instrumentation.

All-in-One:
Reduces sequencing depth and costs.

Accurate:

Improves microbial reads with
integrated host depletion.

Accelerated:

Delivers results in
under 24 hours.

Adaptable:

Accommodates a wide range of
sample types and applications.

Affordable:

Reduces sequencing
depth and costs.

Automatable:

Boosts efficiency with companion
instrumentation.

All-in-One:

A single solution for all types
of microorganisms.

Reducing mNGS Contamination, Complexity and Cost

Microbiome
Research

  • Detect known and novel microorganisms

  • Know your real microbial signals

  • Study more samples for the same cost

  • Lower bias for better results

  • Ensure accurate data analysis

Ensure mNGS Accuracy

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XNA Decontaminating Spray Cleanser

  • Pre-mixed and stabilized
  • Degrades nucleic acids on contact

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Devin™ Host Depletion Filter

  • >99% nucleated host cell depletion

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Devin™ Microbial DNA Enrichment Kits

  • Clean, mNGS-grade™ reagents
  • Genomic DNA yields 10-1000 fold
    microbial enrichment

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Unison Ultralow DNA NGS Library


















Prep Kits

  • Tn5-based with normalizing function 
Six Image

PaRTI-Seq RUO Analysis

  • Free data download code with kit

Clinical Microbiology

  • Reduce costs for difficult to identify pathogens in chronic infections

  • Reduce TATs for acute infections

  • Reduce complexity by fully automating mNGS system

Fully Automated mNGS

image

XNA Decontaminating Spray Cleanser

  • Pre-mixed and stabilized
  • Degrades nucleic acids on contact

Three

Collection Devices

  • Custom-made swabs 
  • PathAlert™ rapid antigen tests 

Devin™ Microbial DNA Enrichment Kit
/ PureBot Automated Instrument

  • Host depletion and genomic DNA extraction
  • < 50 minute extraction time
Automated

One

Unison Ultralow DNA NGS Library Prep Kit /
PrepBot Library Prep Instrument

  • Mitigates carry-over contamination  
  • Reduce hands-on time and human error 
  • Automated

PaRTI-Seq Clinical Analysis

  • Fast cloud-based analysis
  • PaRTIBot on-premise option

Biotechnology

  • Detect antibiotic resistance genes

  • Identify genes encoding bioactive compounds

  • Improve sterility testing with faster, more complete data

  • Manual or automated options

Identify and Develop New Therapies

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XNA Decontaminating Spray Cleanser

  • Pre-mixed and stabilized
  • Degrades nucleic acids on contact

white

Devin™ Host Depletion Filter

  • Remove 99% nucleated host cells 

Nine Image

Devin™ Microbial DNA Enrichment Kit

  • Genomic DNA yields 10-1000 fold
    microbial enrichment
Automated
Manual

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Unison Ultralow DNA NGS Library Prep Kit

  • For NGS, WGS, mNGS, 16S rRNA sequencing, qPCR, end-point PCR 
  • Automated
    Manual

Five Image

PurBot, PrepBot Instrumentation

  • Turnkey mNGS solutions
  • Automated

PaRTI-Seq RUO/Clinical Analysis

  • <30-minutes>
  • Automatic cut-offs

Industrial
Processes

  • Facilitate novel enzyme development

  • Identify agriculturally important microbes

  • Monitor wastewater for outbreaks

  • Increase food safety

  • Enhance sterility testing

Get More Genomic Information Faster

image

XNA Decontaminating Spray Cleanser

  • Pre-mixed and stabilized
  • Degrades nucleic acids on contact

white

Devin™ Host Depletion Filter

  • >99% host leukocyte depletion

Nine Image

Devin™ Microbial DNA Enrichment Kit

  • Genomic DNA yields 10-1000 fold microbial enrichment
Automated
Manual

image

Unison Ultralow DNA NGS Library Prep Kit

  • Fast, reduces hands-on time and errors 
  • Automated
    Manual

Five Image

PureBot, PrepBot Instrumentation

  • Turnkey mNGS solution
  • Automated

Six Image

PaRTI-Seq RUO/Clinical Analysis

  • <30-minutes>
  • Automatic cut-offs

Getting to Know Us

publication icon

Publications

Evaluation of a mNGS Assay with Novel Host Depletion Method for Pathogen Identification in Septic Patients

03.28.2023

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Press

Emerging Infectious Diseases in Thailand Highlight Need for Advanced Diagnostic Solutions

09.24.2024

events

Events

Integrating mNGS into Clinical Practice – Challenges and Opportunities

Taipei, Taiwan (TaiNex1)
December 6, 2024

blogs icon

Blogs

The Hidden Crisis in Infectious Disease Diagnostics: When Tests Fail to Identify the Causal Pathogen

September 2024

Innovating Together

See our collaboration and distribution partners around the world.

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