Innovating Metagenomics

Metagenomics offers a unique opportunity to examine microbial genomes without culturing the organisms in an aseptic environment. Moreover, metagenomics Next-Generation Sequencing (mNGS) provides fast and precise identification of all types of known and novel bacteria, viruses, fungi, and parasites.  Despite its speed and accuracy, mNGS is just beginning to be widely used due to several technological- and resource-related issues. That’s where Micronbrane Medical comes in. We develop mNGS products that remove the barriers to ubiquitous use in all types of settings.

Collection Devices

Custom-made oral, nasal, nasopharyngeal swabs, and rapid diagnostic test kits.

Start the process off right with collection devices that quickly and cleanly collect all types of biological fluids.  Devices can be sterile/non-sterile and comply with ISO13485, GMP and QMS standards. 

For more information about our collection devices please refer to our product catalog.

Patented Devin™ Host Depletion filter 

New types of filters in 2024!

Host Depletion

The presence of larger eukaryotic genomes can obfuscate sequencing signals from microbial genomes. The Devin Host Depletion filter is a proprietary fractionation syringe filter that effectively removes host background signals from liquid biopsies such as whole blood, plasma, cerebral spinal fluid (CSF), bronchoalveolar lavage (BAL), synovial, ophthalmic fluids, feces, and urine. The patented technology, called Zwitterionic Interface Ultra Self-assemble Coating (ZISC), depletes host nucleated cells while allowing bacterial, viral, fungi, and parasite communities to pass through unaltered. 

  • < 5 min processing time
  • >99% leukocyte depletion
  • >90% microbial output
  • NOT based on size exclusion

Devin Microbial Enrichment Kit

Enrichment and Purification

The Devin Microbial DNA Enrichment Kit is a fast and simple genomic nucleic acid purification protocol specifically designed using mNGS-grade reagents to minimize contamination. The kit begins with the Devin filter to deplete host nucleated cells from liquid biopsies. Extractions with the kit, after host depletion, are also compatible with automated systems, facilitating high-throughput NGS assays.

  • 10 – 1000 fold microbial enrichment
  • Process samples within 1.5 hours
  • Optimizes extraction conditions for both Gram- and Gram+ bacteria
  • Produces high-quality, high-yield genomic DNA
  • Compatible with NGS, 16S rRNA sequencing, qPCR, and end-point PCR protocols

Unison™ Ultralow Library Prep Kit

RNA and 2 more kits in 2024!

Library Preparation

The Unison Ultralow DNA NGS Library Preparation Kit optimizes the preparation of NGS libraries for low-input DNA (as little as 10 pg) extracts. The kit also accelerates DNA library preparations by utilizing a proprietary tagmentation-based method which condenses fragmentation, adapter ligation, and normalization steps into a single step. Specifically optimized for high molecular weight DNA the kit generates library fragments whose sizes are optimal for Illumina platforms at normalized concentrations.

Unison provides you with pure, high-quality DNA extracts that enable multiplexing each sequencing run. By effectively reducing host contamination right from the start, the sequencing depth required to achieve a representative microbiome sample can be reduced by several fold. This reduces sequencing costs and shortens overall sequencing time, depending on the downstream sequencing platforms.

Unison is:
  • Compatible with double-stranded DNA (>1Kb) inputs
  • 1-5 ng or as low as 10 pg DNA input
  • Tn5-based method
  • Minimal hands-on time at 45 minutes
  • Reduced total processing times at 150 minutes.
  • Optimized genomic DNA workflow

PaRTI-Cular™ Bioinformatic Web App

Analysis and Action

To streamline the entire mNGS workflow, our PaRTI-Cular™ Bioinformatic Web App ensures fast reporting of results. The platform is curated with up-to-date genome information for thousands of microorganisms. PaRTI-Cular also comes with proper database benchmarking and robust analysis of microbial pathogens with unusual sequence homologies and/or close taxonomic relationships, reducing false-positive or false-negative results. PaRTI-Cular is available by the reaction or as an annual subscription.

PaRTI-Cular’s state-of-the-art computational algorithms provide a complete report within 30 minutes per sample. The cloud-based software also automatically conducts data quality checks, removal of host genome reads, pathogen identification, and statistical analyses.

  • Automatic cutoff of background noise 
  • Thoroughly curated and regularly updated database comprising over 1400 pathogens
  • Proprietary reference database (healthy individuals baseline) for comprehensive analysis
  • Genome coverage for pathogens with highest concentration  
  • Data analysis featuring abundance distributions  for infected individuals vs normal (healthy) individuals

Micronbrane Medical’s Pathogen Real-Time Identification (PaRTI-Seq) assay is a cost-effective solution to from collection to action within 24 hours.



We make it easy and economical to implement mNGS in your lab.

PaRTI-Seq
Micro-L

Devin Host Depletion Filters

x1

Unison Ultralow Library Kit

x1

Description
  • 8 reactions using your own extraction kit
  • Any liquid biopsy
  • RUO
PaRTI-Seq
Micro-R

Devin Host Depletion Filters

x1

Unison Ultralow Library Kit

x1

PaRTI-Cular
Data only

Description
  • 8 reactions
  • Any liquid biopsy
  • COA for mNGS-grade reagents
  • RUO
PaRTI-Seq
Micro-P

Devin Microbial Enrichment Kit

x1

Unison Ultralow Library Kit

x1

PaRTI-Cular
Bioinformatic analysis

Description
  • 8 reactions
  • Any liquid biopsy
  • COA for mNGS-grade reagents
  • Code allows 8 PaRTI-Cular analysis and reports
  • RUO
PaRTI-Seq
Lite Kit

Devin Host Depletion Filters

x48

Unison Ultralow Library Prep Kit

x1

Description
  • 48 reactions using your own extraction kit
  • Any liquid biopsy
PaRTI-Seq
Research Kit

Devin Microbial Enrichment Kits

x2

Unison Ultralow Library Preparation Kit

x1

PaRTI-Cular
Data only

Description
  • 48 reactions
  • Any liquid biopsy
  • COA for mNGS reagents
  • RUO
PaRTI-Seq
Plus Kit

Devin Microbial Enrichment Kits

x2

Unison Ultralow Library Kit

x1

PaRTI-Cular
Bioinformatic
Analysis

Description
  • 48 reactions
  • Any liquid biopsy
  • COA for mNGS reagents
  • Code unlocks 48 PaRTI-Cular data download
PaRTI-Seq
MAX

Devin Microbial Enrichment Kits

x20

Unison Ultralow Library Kits

x10

PaRTI-Cular
Bioinformatics analysis

Description
  • 480 reactions
  • COA for mNGS-grade reagents
  • 480 Analysis and reports
PaRTI-Seq
ANNUAL

<30 mins / sample analysis and reporting

Automatic cutoff of background noiseu00a0

Over 1400 pathogens

Description
  • 12 months
  • Unlimited seats
  • Unlimited analysis